Endocrine Abstracts

Introduction: Cushing’s syndrome (CS) is rare in children. The most common cause of CS in children is exogenous or iatrogenic CS. The most common cause of endogenous CS is Cushing disease (CD). Pediatric CD is almost always caused by a pituitary microadenoma. Here we present a rare case of (CD) related to pituitary macroadenoma.Clinical observation: An 11 year old boy presented with complaints of excessive appetite and progressive weight gain. He ha...

Introduction: The association of primary hyperparathyroidism (PHPT) and hyperthyroidism secondary to toxic multinodular goiter (TMNG) is rarely described in the literature. Hereby, we describe the clinical, biological, and radiological characteristics of two patients having this rare association.Observations: First case: A 66 years-old female was diagnosed with primary hyperthyroidism. Her thyroid antibodies were negatives. During the follow-up, she pres...

Introduction: The pathophysiology of diabetic nephropathy is characterized by proteinuria which often precedes the decline in creatinine clearance. The objective of our study was to describe the clinical and metabolic characteristics of a population of diabetic femele patients with renal failure without proteinuria.Methods: This is a retrospective study that included 37 diabetic women who had been hospitalized at the National Institute of Nutrition of Tu...

Introduction: Neuroendocrine tumors may develop in almost any organ. These types of tumors may present with giant and asymptomatic mass. We describe a case of a large non functional neuroendocrine tumor reported in the department of endocrinology and diabetology of Hedi Chaker hospital in Sfax-Tunisia in 2016.Presentation of case: A 28 years old male presented with asthenia, gastric heaviness and epigastric pain. Further computerized tomography, a large ...

Introduction: Multiple autoimmune syndrome (MAS) is a rare condition, first described by Humbert and Dupond in 1988 and characterised by three or more autoimmune disorders in the same individual.Case description: Here we present a case of 14-year-old female patient diagnosed with ocular myasthenia gravis. The diagnosis of Graves’ disease was suspected on the basis of hyperthyroidism symptoms and confirmed by undetectable TSH level (<0.01 mUI/l) ...

Introduction: Disorders of sex development (DSD) is a congenital condition in which the development of chromosomal, gonadal or genital sex is atypical. A female appearance patient with secondary amenorrhea and 46 XY karyotype seems to be solid evidences to diagnose Y-chromosome-related DSD diseases, while it is not necessarily the accurate diagnosis. We here report a case of a 16- year-old girl with secondary amenorrhea and 46 XY karyotype after bone marrow transplantation (BM...